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Periodicity in $Na^+$ channel properties alters excitability of a model neuron

Majumdar, Sriparna and Sikdar, Sujit K (2007) Periodicity in $Na^+$ channel properties alters excitability of a model neuron. In: Biochemical and Biophysical Research Communications, 359 (4). pp. 908-914.

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The voltage gated Na channels play vital role in action potential waveform shaping and propagation. We have shown earlier that the duration and amplitude of a prolonged depolarization alter all the steady state and kinetic parameters of $rNa_V1.2a$ voltage gated Na channel in a pseudo-oscillatory fashion. In the present study, we show that the Hodgkin–Huxley voltage and time dependent rate constants of activation ($\alpha_m$ and $\beta_m$) and fast inactivation ($\alpha_h$ and $\beta_h$), obtained from the analyses of Na currents and steady state activation and inactivation plots, following application of prepulses in both slow (1–100 s) and fast (100–1000 ms) ranges, vary with the duration of a prepulse in a pseudo-oscillatory manner. Using these Hodgkin–Huxley kinetic parameters in simulation, the excitability and firing pattern of a model neuron are shown to vary in a history dependent periodic fashion.

Item Type: Journal Article
Publication: Biochemical and Biophysical Research Communications
Publisher: Elsevier
Additional Information: Copyright of this article belongs to Elsevier.
Keywords: Voltage gated Na channel;Hodgkin–Huxley formalism;Single neuron simulation;Excitability;Action potential
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 11 Jun 2008
Last Modified: 19 Sep 2010 04:45
URI: http://eprints.iisc.ac.in/id/eprint/14287

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