Clavel, Caroline and Canales, Angeles and Gupta, Garima and Canada, Javier F and Penades, Soledad and Surolia, Avadhesha and Jimenez, Jesus B (2007) NMR Investigation of the Bound Conformation of Natural and Synthetic Oligomannosides to Banana Lectin. In: European Journal of Organic Chemistry, 2007 (10). pp. 1577-1585.
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Abstract
The conformational behaviour of three mannose-containing oligosaccharides, namely, the $\alpha1 \rightarrow 3[\alpha1 \rightarrow 6]$ trisaccharide, a heptasaccharide with $\alpha1 \rightarrow 2$, $\alpha1 \rightarrow 3$ and $\alpha1 \rightarrow 6$ linkages and a tetrasaccharide consisting of $\alpha1 \rightarrow 3$ and $\alpha1 \rightarrow 2$ linkages, when bound to banana lectin (BanLec) has been evaluated by trNOE NMR methods and docking calculations. It was found that the molecular recognition event involves a conformational selection process with only one of the conformations present in the free state of the sugar being recognised at the lectin binding site.
Item Type: | Journal Article |
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Publication: | European Journal of Organic Chemistry |
Publisher: | John Wiley & Sons, Inc. |
Additional Information: | Copyright of this article belongs to John Wiley & Sons, Inc. |
Keywords: | Mannose oligosaccharides;NMR spectroscopy;Molecular dynamics;Banana lectin;Molecular recognition |
Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
Date Deposited: | 03 Jun 2008 |
Last Modified: | 19 Sep 2010 04:45 |
URI: | http://eprints.iisc.ac.in/id/eprint/14137 |
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