Ramesh, N and Shouche, Yogesh S and Brahmachari, Samir K (1986) Recognition of B and Z forms of DNA by Escherichia coli DNA polymerase I. In: Journal of Molecular Biology, 190 (4). pp. 635-638.
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Abstract
Since the substrate binding domain of the large proteolytic fragment of E.coli DNA polymerase I has been shown to interact with the B forms of DNA, the ability of this enzyme to recognize structures other than the B form was studied.The polymerase activity has been used to evaluate the degree of recognition of the B and Z forms of DNA.The Z form was found to promote less activity, indicating the probable inability of the polymerase to move along the conformationally rigid form of the template.The present study indicates that the Z-DNA found in vivo may have a role in the control of replication.
Item Type: | Journal Article |
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Publication: | Journal of Molecular Biology |
Publisher: | Elsevier Ltd. |
Additional Information: | Copyright belongs to Elsevier Ltd. |
Keywords: | DNA polymerase |
Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
Date Deposited: | 09 May 2008 |
Last Modified: | 19 Sep 2010 04:44 |
URI: | http://eprints.iisc.ac.in/id/eprint/13913 |
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