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Mechanism of inactivation of HMGCoA reductase

Ramasarma, T and Devi, Usha S (1987) Mechanism of inactivation of HMGCoA reductase. In: Indian Journal of Biochemistry & Biophysics, 24 (5). pp. 33-35.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/3449438


A review with 10 references, on 2 types of rapid inactivation of the activity of microsomal hydroxymethylglutaryl-CoA (HMG-CoA) reductase. The 1st involves the cytosolic protein, fermodulin, and free $Fe^{2+}$, which appear to mask the SH groups at the active site. The 2nd uses the hemin-dependent oxidn. of dithiol groups in the presence of $O_2$, leading to inactivation of the enzyme.

Item Type: Journal Article
Publication: Indian Journal of Biochemistry & Biophysics
Publisher: The Council of Scientific & Industrial Research
Additional Information: Copyright of this article belongs to The Council of Scientific & Industrial Research.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 05 May 2008
Last Modified: 22 Oct 2010 05:17
URI: http://eprints.iisc.ac.in/id/eprint/13833

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