Ramasarma, T and Devi, Usha S (1987) Mechanism of inactivation of HMGCoA reductase. In: Indian Journal of Biochemistry & Biophysics, 24 (5). pp. 33-35.
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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/3449438
Abstract
A review with 10 references, on 2 types of rapid inactivation of the activity of microsomal hydroxymethylglutaryl-CoA (HMG-CoA) reductase. The 1st involves the cytosolic protein, fermodulin, and free $Fe^{2+}$, which appear to mask the SH groups at the active site. The 2nd uses the hemin-dependent oxidn. of dithiol groups in the presence of $O_2$, leading to inactivation of the enzyme.
| Item Type: | Journal Article |
|---|---|
| Publication: | Indian Journal of Biochemistry & Biophysics |
| Publisher: | The Council of Scientific & Industrial Research |
| Additional Information: | Copyright of this article belongs to The Council of Scientific & Industrial Research. |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 05 May 2008 |
| Last Modified: | 22 Oct 2010 05:17 |
| URI: | http://eprints.iisc.ac.in/id/eprint/13833 |
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