Interaction of non-intercalative drugs with DNA: Distamycin analogues

Rajagopalan, Malini and Ayyer, Jayalekshmy and Sasisekharan, V (1985) Interaction of non-intercalative drugs with DNA: Distamycin analogues. In: Journal of Biosciences, 7 (1). pp. 27-32.

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Abstract

Distamycin and netropsin are two oligopeptides which bind to DNA in a nonintercalative manner. Analogues of distamycin have been synthesized and their binding with poly d(A-T) studied using ultraviolet absorption spectroscopy. Preliminary biological activity tests on a gram positive bacteria using these analogues have also been carried out.

Item Type:	Journal Article
Publication:	Journal of Biosciences
Publisher:	The Indian Academy of Sciences
Additional Information:	Copyright belongs to The Indian Academy of Sciences
Keywords:	Non-intercalative binding;DNA;distamycin analogues
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	19 Mar 2008
Last Modified:	19 Sep 2010 04:43
URI:	http://eprints.iisc.ac.in/id/eprint/13423

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