Studies on the conformations of sialyloligosaccharides and implications on the binding specificity of neuraminidases

Veluraja, K and Rao, VSR (1984) Studies on the conformations of sialyloligosaccharides and implications on the binding specificity of neuraminidases. In: Journal of Biosciences, 6 (5). pp. 625-634.

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Abstract

Theoretical investigations, using semi-empirical potential functions have been carried out to predict the favoured conformations of the terminal dissaccharide fragments of various sialyloligosaccharides. The proposed conformational similarity for these fragments has been correlated to the binding specificity of neuraminidases. These calculations predict that bacterial neuraminidases have a binding site which can accommodate only two sugar residues and virus neuraminidases have a binding site which can accommodate more than two sugar residues.

Item Type:	Journal Article
Publication:	Journal of Biosciences
Publisher:	Indian Academy of Sciences
Additional Information:	Copyright of this article belongs to Indian Academy of Sciences.
Keywords:	Conformation;N-acetylneuraminic acid;neuraminidases;sialic acid;sialyloligosaccharides
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	25 Mar 2008
Last Modified:	19 Sep 2010 04:43
URI:	http://eprints.iisc.ac.in/id/eprint/13402

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