Non-standard amino acids in peptide design and protein engineering

Balaram, Padmanabhan (1992) Non-standard amino acids in peptide design and protein engineering. In: Current Opinion in Structural Biology, 2 (6). pp. 845-851.

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Abstract

The introduction of non-coded amino acids with well defined stereochemical and functional properties will greatly enhance the scope of protein design and engineering. The present state of methodologies for incorporation of non-coded residues into proteins is examined. The prospects for conformationally constrained amino acid residues are evaluated in the light of peptide structural studies. Templates for secondary-structure nucleation and recent experiences in the incorporation of novel residues into proteins are considered.

Item Type:	Journal Article
Publication:	Current Opinion in Structural Biology
Publisher:	Elsevier Science Ltd.
Additional Information:	Copyright of this article belongs to Elsevier Science Ltd.
Keywords:	amino-cycloalkane-1-carboxylic acid;α-aminoisobutyric acid;human immunodeficiency virus;lactic acid;pipecolic acid
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	19 Feb 2008
Last Modified:	22 Dec 2010 10:18
URI:	http://eprints.iisc.ac.in/id/eprint/12878

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