Bilayers containing calcium ionophore A23187 form channels

Balasubramanian, SV and Sikdar, SK and Easwaran, KRK (1992) Bilayers containing calcium ionophore A23187 form channels. In: Biochemical and Biophysical Research Communications, 189 (2). pp. 1038-1042.

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Abstract

For the first time, based on bilayer membrane conductance experiments, it has been shown that A23187, a carboxylic calcium ionophore, incorporated in lipid bilayers gives single channel currents similar to the well known gramicidin channel. The current characteristics indicate the possibility that the transmembrane ion transport by this important calcium ionophore is initially by a carrier mechanism but with time is by a channel or pore mechanism due to the aggregation of the molecule in a lipid matrix.

Item Type:	Journal Article
Publication:	Biochemical and Biophysical Research Communications
Publisher:	Elsevier Inc.
Additional Information:	Copyright of this article belongs to Elsevier Inc.
Keywords:	calcium ionophore;carboxylic calcium ionophore;
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	23 Feb 2008
Last Modified:	19 Sep 2010 04:42
URI:	http://eprints.iisc.ac.in/id/eprint/12855

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