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Effect of 5-fluorouracil on interleukin-2 expression

Balaji, KN and Nayak, R (1992) Effect of 5-fluorouracil on interleukin-2 expression. In: Biochemical and Biophysical Research Communications, 187 (1). pp. 305-309.

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The effect of 5-fluorouracil on the expression of IL-2 gene and the production of IL-2 protein has been studied using spleenic lymphocytes of rats. The IL-2 messenger RNA has been quantitated by dot-blots and IL-2 has been assayed by Con A-blast assay. The results show that there is up to 3.75 fold increase in the production of IL-2 message in 5-fluorouracil treated lymphocytes over Con A treated controls. There is also a concomitant increase in IL-2 protein production upon 5-fluorouracil treatment in rat lymphocytes.

Item Type: Journal Article
Publication: Biochemical and Biophysical Research Communications
Publisher: Elsevier Inc.
Additional Information: Copyright of this article belongs to Elsevier Inc.
Keywords: fluorouracil;interleukin;rat lymphocytes
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 12 Feb 2008
Last Modified: 19 Sep 2010 04:41
URI: http://eprints.iisc.ac.in/id/eprint/12747

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