Effect of 5-fluorouracil on interleukin-2 expression

Balaji, KN and Nayak, R (1992) Effect of 5-fluorouracil on interleukin-2 expression. In: Biochemical and Biophysical Research Communications, 187 (1). pp. 305-309.

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Abstract

The effect of 5-fluorouracil on the expression of IL-2 gene and the production of IL-2 protein has been studied using spleenic lymphocytes of rats. The IL-2 messenger RNA has been quantitated by dot-blots and IL-2 has been assayed by Con A-blast assay. The results show that there is up to 3.75 fold increase in the production of IL-2 message in 5-fluorouracil treated lymphocytes over Con A treated controls. There is also a concomitant increase in IL-2 protein production upon 5-fluorouracil treatment in rat lymphocytes.

Item Type:	Journal Article
Publication:	Biochemical and Biophysical Research Communications
Publisher:	Elsevier Inc.
Additional Information:	Copyright of this article belongs to Elsevier Inc.
Keywords:	fluorouracil;interleukin;rat lymphocytes
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	12 Feb 2008
Last Modified:	19 Sep 2010 04:41
URI:	http://eprints.iisc.ac.in/id/eprint/12747

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