Analysis of DNA curvature distribution in mycobacterial promoters using theoretical models

Kalate, Rupali N and Kulkarni, BD and Nagaraja, V (2002) Analysis of DNA curvature distribution in mycobacterial promoters using theoretical models. In: Biophysical Chemistry, 99 . pp. 77-97.

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Abstract

In this paper, 125 different mycobacterial promoters are analyzed for their DNA curvature distribution using several di- and tri-nucleotide dependent models of DNA curvature. Different models give similar behavior and therefore qualitative validation of the results. Mycobacterial promoters resembling the E. coli s type have almost 81% (85%) 70sequences having medium and high curvature profiles using dinucleotide-dependent models. Non-E. coli s type mycobacterial promoters have comparatively higher percent of low curvature profiles. Very few extended y10 promoters have low curvature profiles. Mycobacterial promoters having A T (nqmG3) tract in the upstream region of -35 box and repeated in phase with each other have high curvature profiles. M. smegmatis promoters have high curvature profiles compared to M. tuberculosis promoters

Item Type:	Journal Article
Publication:	Biophysical Chemistry
Publisher:	Elsevier
Keywords:	Mycobacterial promoters;Transcription;Curvature models
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	06 Nov 2004
Last Modified:	19 Sep 2010 04:14
URI:	http://eprints.iisc.ac.in/id/eprint/1111

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