Kalate, Rupali N and Kulkarni, BD and Nagaraja, V (2002) Analysis of DNA curvature distribution in mycobacterial promoters using theoretical models. In: Biophysical Chemistry, 99 . pp. 77-97.
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Abstract
In this paper, 125 different mycobacterial promoters are analyzed for their DNA curvature distribution using several di- and tri-nucleotide dependent models of DNA curvature. Different models give similar behavior and therefore qualitative validation of the results. Mycobacterial promoters resembling the E. coli s type have almost 81% (85%) 70sequences having medium and high curvature profiles using dinucleotide-dependent models. Non-E. coli s type mycobacterial promoters have comparatively higher percent of low curvature profiles. Very few extended y10 promoters have low curvature profiles. Mycobacterial promoters having A T (nqmG3) tract in the upstream region of -35 box and repeated in phase with each other have high curvature profiles. M. smegmatis promoters have high curvature profiles compared to M. tuberculosis promoters
Item Type: | Journal Article |
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Publication: | Biophysical Chemistry |
Publisher: | Elsevier |
Keywords: | Mycobacterial promoters;Transcription;Curvature models |
Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
Date Deposited: | 06 Nov 2004 |
Last Modified: | 19 Sep 2010 04:14 |
URI: | http://eprints.iisc.ac.in/id/eprint/1111 |
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