Multifaceted role of CTCF in X-chromosome inactivation

Bammidi, LS and Gayen, S (2024) Multifaceted role of CTCF in X-chromosome inactivation. In: Chromosoma .

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Abstract

Therian female mammals compensate for the dosage of X-linked gene expression by inactivating one of the X-chromosomes. X-inactivation is facilitated by the master regulator Xist long non-coding RNA, which coats the inactive-X and facilitates heterochromatinization through recruiting different chromatin modifiers and changing the X-chromosome 3D conformation. However, many mechanistic aspects behind the X-inactivation process remain poorly understood. Among the many contributing players, CTCF has emerged as one of the key players in orchestrating various aspects related to X-chromosome inactivation by interacting with several other protein and RNA partners. In general, CTCF is a well-known architectural protein, which plays an important role in chromatin organization and transcriptional regulation. Here, we provide significant insight into the role of CTCF in orchestrating X-chromosome inactivation and highlight future perspectives. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

Item Type:	Journal Article
Publication:	Chromosoma
Publisher:	Springer Science and Business Media Deutschland GmbH
Additional Information:	The copyright for this article belongs to publisher.
Keywords:	long untranslated RNA, chromatin; female; gene expression; human; review; therian; X chromosome; X chromosome inactivation
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	19 Nov 2024 20:24
Last Modified:	19 Nov 2024 20:24
URI:	http://eprints.iisc.ac.in/id/eprint/86776

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