Srivatzen, S and Kavitha, BS and Asokan, S (2024) SU-8 coated etched fiber Bragg grating sensors: A versatile platform for detection of any biomarker using antibody-antigen chemistry. In: CLEO: Science and Innovations, CLEO: S and I 2024 in Proceedings CLEO 2024, Part of Conference on Lasers and Electro-Optics, 5 May 2024 through 10 May 2024, Charlotte.
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Biomarker detection is pivotal in various fields, including healthcare, environmental monitoring, and biotechnology. This work introduces a versatile platform for biomarker detection by utilizing SU-8 negative photoresist coated etched Fiber Bragg Grating (eFBG) sensors in conjunction with antibody-antigen chemistry. The unique combination of FBG sensors and SU-8 coating offers several advantages, including enhanced sensitivity, selectivity, and versatility. In this study, we present the design and fabrication of SU-8 coated FBG sensors optimized for biomarker detection. The SU-8 coating not only provides a stable and biocompatible surface for immobilizing antibodies but also improves the sensor's response to specific antigen binding. As a proof of concept, the detection of concentration of standard antigen is demonstrated by functionalization of the SU-8 coated eFBG sensor with corresponding IgG antibody using EDC/NHS crosslinking chemistry. The reflected Bragg wavelength (lB) of the eFBG sensor is modulated by the added antigen concentration. The dynamic range of the sensor is from 8 pg/ml to 80 ng/ml with average sensitivity of 32.3 pm 10-1 g-1 ml. © Optica Publishing Group 2024
| Item Type: | Conference Paper |
|---|---|
| Publication: | CLEO: Science and Innovations, CLEO: S and I 2024 in Proceedings CLEO 2024, Part of Conference on Lasers and Electro-Optics |
| Publisher: | Optical Society of America |
| Additional Information: | The copyright for this article belongs to the publishers. |
| Keywords: | Antigens; Biomarkers; Chemical detection; Chemical sensors; Crosslinking; Fiber Bragg gratings; Fiber optic chemical sensors, A-stable; Antibody-antigen; Enhanced sensitivity; Environmental biotechnology; Environmental Monitoring; Etched fiber bragg grating; FBG sensor; Fiber Bragg Grating Sensors; Negative photoresists; Stable surfaces, Photoresists |
| Department/Centre: | Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics |
| Date Deposited: | 30 Oct 2024 05:53 |
| Last Modified: | 30 Oct 2024 05:53 |
| URI: | http://eprints.iisc.ac.in/id/eprint/86571 |
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