Order/Disorder Transitions Upon Protein Binding: A Unifying Perspective

Lebedenko, O and Sekhar, A and Skrynnikov, N (2024) Order/Disorder Transitions Upon Protein Binding: A Unifying Perspective. In: Proteins: Structure, Function and Bioinformatics .

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Abstract

When two proteins bind to each other, this process is often accompanied by a change in their structural states (from disordered to ordered or vice versa). As it turns out, there are 10 distinct possibilities for such binding-related order/disorder transitions. Out of this number, seven scenarios have been experimentally observed, while another three remain hitherto unreported. As an example, we discuss the so-called mutual synergistic folding, whereby two disordered proteins come together to form a fully structured complex. Our bioinformatics analysis of the Protein Databank found potential new examples of this remarkable binding mechanism. © 2024 The Author(s). PROTEINS: Structure, Function, and Bioinformatics published by Wiley Periodicals LLC.

Item Type:	Journal Article
Publication:	Proteins: Structure, Function and Bioinformatics
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to authors.
Keywords:	article; bioinformatics; electric potential; protein binding; protein unfolding
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	15 Sep 2024 10:34
Last Modified:	15 Sep 2024 10:34
URI:	http://eprints.iisc.ac.in/id/eprint/86092

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