Guin, A and Biju, AT (2024) Ring-Opening 1,3-Bisfunctionalization of Donor-Acceptor Cyclopropanes. [Book Chapter]
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Donor-acceptor (D-A) cyclopropanes are highly electrophilic intermediates because of the inherent strain present in the three-membered ring. Several nucleophiles can add to the D-A cyclopropanes to open the three-membered ring and subsequently, a carbanion generates at the acceptor terminus. If the negative charge is trapped with a suitable electrophile, it will lead to 1,3-bisfunctionalization of D-A cyclopropanes. Lewis acid-catalyzed 1,3-bisfunctionalization of donor-acceptor cyclopropanes can be achieved through the insertion reaction of a suitable nucleophile-electrophile combination or through multicomponent coupling reaction. In this chapter, we summarize the noteworthy ring-opening 1,3-bisfunctionalization of D-A cyclopropanes reported to date. © 2024 Wiley-VCH GmbH, Boschstra�e 12, 69469 Weinheim, Germany.
| Item Type: | Book Chapter |
|---|---|
| Publication: | Donor- Acceptor Cyclopropanes in Organic Synthesis |
| Publisher: | wiley |
| Additional Information: | The copyright for this article belongs to wiley. |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 22 Sep 2024 06:58 |
| Last Modified: | 22 Sep 2024 06:58 |
| URI: | http://eprints.iisc.ac.in/id/eprint/85269 |
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