An integrative systems biology approach identifies molecular signatures associated with gallbladder cancer pathogenesis

Roy, N and Kshattry, M and Mandal, S and Jolly, MK and Bhattacharyya, DK and Barah, P (2021) An integrative systems biology approach identifies molecular signatures associated with gallbladder cancer pathogenesis. In: Journal of Clinical Medicine, 10 (16).

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Abstract

Gallbladder cancer (GBC) has a lower incidence rate among the population relative to other cancer types but is a major contributor to the total number of biliary tract system cancer cases. GBC is distinguished from other malignancies by its high mortality, marked geographical variation and poor prognosis. To date no systemic targeted therapy is available for GBC. The main objective of this study is to determine the molecular signatures correlated with GBC development using integrative systems level approaches. We performed analysis of publicly available transcriptomic data to identify differentially regulated genes and pathways. Differential co-expression network analysis and transcriptional regulatory network analysis was performed to identify hub genes and hub transcription factors (TFs) associated with GBC pathogenesis and progression. Subsequently, we assessed the epithelial-mesenchymal transition (EMT) status of the hub genes using a combination of three scoring methods. The identified hub genes including, CDC6, MAPK15, CCNB2, BIRC7, L3MBTL1 were found to be regulators of cell cycle components which suggested their potential role in GBC pathogenesis and progression. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Item Type:	Journal Article
Publication:	Journal of Clinical Medicine
Publisher:	MDPI AG
Additional Information:	The copyright for this article belongs to Authors
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	18 Oct 2021 10:03
Last Modified:	18 Oct 2021 10:03
URI:	http://eprints.iisc.ac.in/id/eprint/69818

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