Decoding leader cells in collective cancer invasion

Vilchez Mercedes, SA and Bocci, F and Levine, H and Onuchic, JN and Jolly, MK and Wong, PK (2021) Decoding leader cells in collective cancer invasion. In: Nature Reviews Cancer .

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Abstract

Collective cancer invasion with leader�follower organization is increasingly recognized as a predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by creating invasion tracks, sensing environmental cues and coordinating with follower cells biochemically and biomechanically. With the latest developments in experimental and computational models and analysis techniques, the range of specific traits and features of leader cells reported in the literature is rapidly expanding. Yet, despite their importance, there is no consensus on how leader cells arise or their essential characteristics. In this Perspective, we propose a framework for defining the essential aspects of leader cells and provide a unifying perspective on the varying cellular and molecular programmes that are adopted by each leader cell subtype to accomplish their functions. This Perspective can lead to more effective strategies to interdict a major contributor to metastatic capability. © 2021, Springer Nature Limited.

Item Type:	Journal Article
Publication:	Nature Reviews Cancer
Publisher:	Nature Research
Additional Information:	The copyright for this article belongs to Nature Research
Keywords:	computer model; consensus; controlled study; human; leadership; review; tumor invasion
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	18 Oct 2021 09:58
Last Modified:	18 Oct 2021 09:58
URI:	http://eprints.iisc.ac.in/id/eprint/69700

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