Thermo-optic measurements and their inter-dependencies for delineating cancerous breast biopsy tissue from adjacent normal

Pal, UM and Vishnu GK, A and Varma, M and Vaidya, JS and Pandya, HJ (2021) Thermo-optic measurements and their inter-dependencies for delineating cancerous breast biopsy tissue from adjacent normal. In: Journal of Biophotonics, 14 (8).

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Abstract

The histopathological diagnosis of cancer is the current gold standard to differentiate normal from cancerous tissues. We propose a portable platform prototype to characterize the tissue's thermal and optical properties, and their inter-dependencies to potentially aid the pathologist in making an informed decision. The measurements were performed on 10 samples from five subjects, where the cancerous and adjacent normal were extracted from the same patient. It was observed that thermal conductivity (k) and reduced-scattering-coefficient (μ's) for both the cancerous and normal tissues reduced with the rise in tissue temperature. Comparing cancerous and adjacent normal tissue, the difference in k and μ's (at 940 nm) were statistically significant (p = 7.94e-3), while combining k and μ's achieved the highest statistical significance (6.74e-4). These preliminary results promise and support testing on a large number of samples for rapidly differentiating cancerous from adjacent normal tissues. © 2021 Wiley-VCH GmbH

Item Type:	Journal Article
Publication:	Journal of Biophotonics
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to John Wiley and Sons Inc
Keywords:	Biopsy; Histology; Optical properties; Thermal conductivity, Cancerous tissues; Histopathological diagnosis; Informed decision; Inter-dependencies; Number of samples; Reduced scattering coefficients; Statistical significance; Tissue temperatures, Tissue
Department/Centre:	Division of Electrical Sciences > Electronic Systems Engineering (Formerly Centre for Electronic Design & Technology) Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Date Deposited:	25 Aug 2021 06:45
Last Modified:	25 Aug 2021 06:45
URI:	http://eprints.iisc.ac.in/id/eprint/69369

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