Photochemical and photocytotoxic evaluation of new Oxovanadium (IV) complexes in photodynamic application

Sanasam, B and Raza, MK and Musib, D and Roy, M (2021) Photochemical and photocytotoxic evaluation of new Oxovanadium (IV) complexes in photodynamic application. In: Journal of Chemical Sciences, 133 (2).

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Abstract

Four new ternary Oxovanadium(IV) complexes, VO(L)(B1-4)(acac), where, L = (E)-2- (2-hydroxybenzylideneamino)-5-guanidinopentanoic acid (Argininesalisylidene) and B were 1H-imidazo-4,5-f1,10-phenanthroline (B1) (1), 2-phenyl-1H-imidazo 4,5-f1,10 phenanthroline (B2) (2), 2-(naphthalen-1-yl)-1H-imidazo 4,5-f1,10 phenanthroline (B3) (3) or 1-(pyren-2-yl)-1H-imidazo4,5-f1,10 phenanthroline (B4) (4) were synthesized, characterized and photocytotoxicity in A549 cell were studied in dark and visible light (400�700 nm, 10 J cm�2). Photochemistry of the complexes (1-4) related to the generation of singlet oxygen (1O2) was studied in detail. The presence of triplet excited state in the complexes was probed from perylene assay. Photo-activated generation of singlet oxygen from the complexes was probed by DPBF assay and the degree of photo-cytotoxicity of the complexes was related to their ability in photo-activated 1O2 generation. Complexes 4 exhibited remarkable photocytotoxicity in A549 cells with photo index (PI) ~ 16 in visible light (400�700 nm, 10 J cm�2) (IC50, 3.81 µM), while complexes were almost less-toxic in dark (IC50, 59.7 µM). Intracellular ROS generation was studied from 2�,7�-dichlorofluorescein diacetate (DCFH-DA). Annexin V-FITC/PI assay suggested apoptotic nature of cell death. Overall, the remarkable photocytotoxic efficacy of the new Oxovanadium(IV) complexes (1-4) making them the potential photochemotherapeutic agents in lieu of porphyrin-based PDT agents. Graphical abstract: Figure not available: see fulltext. © 2021, Indian Academy of Sciences.

Item Type:	Journal Article
Publication:	Journal of Chemical Sciences
Publisher:	Springer
Additional Information:	The copyright for this article belongs to Springer
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	11 Aug 2021 11:24
Last Modified:	11 Aug 2021 11:24
URI:	http://eprints.iisc.ac.in/id/eprint/69092

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