Mesoporous silica nanoparticles capped with chitosan-glucuronic acid conjugate for pH-responsive targeted delivery of 5-fluorouracil

Narayan, R and Gadag, S and Mudakavi, RJ and Garg, S and Raichur, AM and Nayak, Y and Kini, SG and Pai, KSR and Nayak, UY (2021) Mesoporous silica nanoparticles capped with chitosan-glucuronic acid conjugate for pH-responsive targeted delivery of 5-fluorouracil. In: Journal of Drug Delivery Science and Technology, 63 .

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Abstract

In the present work, we designed mesoporous silica nanoparticles (MSNs) capped with chitosan-glucuronic acid (CHS-GCA) conjugate for pH-responsive targeted delivery of 5-fluorouracil (5-FU). The influence of the synthesis parameters on the shape and particle size of the MSNs was investigated. The size and morphology of the MSNs were found to be dependent on the amount of surfactant and inorganic silica source. 5-FU was encapsulated within the mesopores by utilizing three different techniques such as solvent immersion, impregnation and incipient wetness impregnation. A higher loading capacity of 172.5 ± 1.49 mg/g was obtained by the impregnation method. To ensure the controlled release of 5-FU, pH-sensitive chitosan was conjugated with glucuronic acid for enhanced uptake by lectin receptors. The developed 5-FU loaded MSNs coated with CHS-GCA showed a higher release of 82.46 ± 3.45 in pH 5.5 by the end of 72 h as compared to 63.84 ± 1.47 in pH 6.8, suggesting a pH-responsive release. Moreover, the CHS-GCA coated MSNs also showed a sustained release profile in colonic pH. Caecal contents further increased the release rate, which is evident from the higher rate constant. The IC50 of the developed formulations was found to be lower than that of pure 5-FU as observed from the cytotoxicity studies. Thus, we envision that the developed MSNs with a higher 5-FU payload might ensure targeted, controlled delivery of 5-FU to the tumor cells, thus reducing the dose and dose-associated toxicities. © 2021 Elsevier B.V.

Item Type:	Journal Article
Publication:	Journal of Drug Delivery Science and Technology
Publisher:	Editions de Sante
Additional Information:	The copyright for this article belongs to Editions de Sante
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	19 Jul 2021 09:47
Last Modified:	19 Jul 2021 09:47
URI:	http://eprints.iisc.ac.in/id/eprint/68706

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