Tunable Anticancer Activity of Furoylthiourea-Based RuII�Arene Complexes and Their Mechanism of Action

Swaminathan, S and Haribabu, J and Kalagatur, NK and Nikhil, M and Balakrishnan, N and Bhuvanesh, NSP and Kadirvelu, K and Kolandaivel, P and Karvembu, R (2021) Tunable Anticancer Activity of Furoylthiourea-Based RuII�Arene Complexes and Their Mechanism of Action. In: Chemistry - A European Journal .

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Abstract

Fourteen new RuII�arene (p-cymene/benzene) complexes (C1�C14) have been synthesized by varying the N-terminal substituent in the furoylthiourea ligand and satisfactorily characterized by using analytical and spectroscopic techniques. Electrostatic potential maps predicted that the electronic effect of the substituents was mostly localized, with some influence seen on the labile chloride ligands. The structure�activity relationships of the Ru�p-cymene and Ru�benzene complexes showed opposite trends. All the complexes were found to be highly toxic towards IMR-32 cancer cells, with C5 (Ru�p-cymene complex containing C6H2(CH3)3 as N-terminal substituent) and C13 (Ru�benzene complex containing C6H4(CF3) as N-terminal substituent) showing the highest activity among each set of complexes, and hence they were chosen for further study. These complexes showed different behavior in aqueous solutions, and were also found to catalytically oxidize glutathione. They also promoted cell death by apoptosis and cell cycle arrest. Furthermore, the complexes showed good binding ability with the receptors Pim-1 kinase and vascular endothelial growth factor receptor 2, commonly overexpressed in cancer cells. © 2021 Wiley-VCH GmbH

Item Type:	Journal Article
Publication:	Chemistry - A European Journal
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to John Wiley and Sons Inc
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	26 Mar 2021 07:00
Last Modified:	26 Mar 2021 07:00
URI:	http://eprints.iisc.ac.in/id/eprint/68607

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