Friend or Foe? The Role of the Host Cytoskeleton in Cellular Responses to Bacterial Pore Forming Toxins

Kumar, H and Ananthanarayanan, V (2021) Friend or Foe? The Role of the Host Cytoskeleton in Cellular Responses to Bacterial Pore Forming Toxins. In: Journal of the Indian Institute of Science .

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Abstract

Bacterial pore forming toxins (PFTs) are transmembrane proteins produced by pathogenic bacteria that increase infection severity in several instances. PFTs assemble into nano-sized pores on the host plasma membrane, making it permeable to ions and small molecules. As a response to PFTs, the host cell engages in cytoskeleton-mediated repair mechanisms to overcome the damage inflicted to its plasma membrane, and to maintain cellular homeostasis. However, PFTs themselves modulate the cytoskeleton in an attempt to escape host immune responses. Here, we review the changes that PFTs effect on the host cytoskeleton and how the host cell responds to this attack via cytoskeleton-associated pathways. © 2021, Indian Institute of Science.

Item Type:	Journal Article
Publication:	Journal of the Indian Institute of Science
Publisher:	Springer
Additional Information:	The copyright of this article belongs to Springer
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	26 Feb 2021 10:56
Last Modified:	26 Feb 2021 10:56
URI:	http://eprints.iisc.ac.in/id/eprint/68035

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