Dasgupta, D and Pally, D and Saini, DK and Bhat, R and Ghosh, A (2020) Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments**. In: Angewandte Chemie - International Edition .
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Abstract
The invasion of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Investigating the remodeling of local extracellular matrix (ECM) by invading cells can thus provide fundamental insights into the dynamics of cancer progression. In this paper, we use an active untethered nanomechanical tool, realized as magnetically driven nanomotors, to locally probe a 3D tissue culture environment. We observed that nanomotors preferentially adhere to the cancer-proximal ECM and magnitude of the adhesive force increased with cell lines of higher metastatic ability. We experimentally confirmed that sialic acid linkage specific to cancer-secreted ECM makes it differently charged, which causes this adhesion. In an assay consisting of both cancerous and non-cancerous epithelia, that mimics the in vivo histopathological milieu of a malignant breast tumor, we find that nanomotors preferentially decorate the region around the cancer cells. © 2020 Wiley-VCH GmbH
| Item Type: | Journal Article |
|---|---|
| Publication: | Angewandte Chemie - International Edition |
| Publisher: | Wiley-VCH Verlag |
| Additional Information: | The copyright of this article belongs to Wiley-VCH Verlag |
| Keywords: | Adhesives; Cells; Nanotechnology; Tissue culture; Tumors, Adhesive force; Cancer progression; Continuous interactions; Culture environments; Extracellular matrices; Malignant cells; Microenvironments; Tumor microenvironments, Diseases |
| Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering |
| Date Deposited: | 11 Mar 2021 10:15 |
| Last Modified: | 11 Mar 2021 10:15 |
| URI: | http://eprints.iisc.ac.in/id/eprint/67492 |
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