Rapid nuclear magnetic resonance data acquisition with improved resolution and sensitivity for high-throughput metabolomic analysis

Joseph, D and Sukumaran, S and Chandra, K and Pudakalakatti, SM and Dubey, A and Singh, A and Atreya, HS (2020) Rapid nuclear magnetic resonance data acquisition with improved resolution and sensitivity for high-throughput metabolomic analysis. In: Magnetic Resonance in Chemistry . (In Press)

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Abstract

Nuclear magnetic resonance (NMR)-based metabolomics has witnessed rapid advancements in recent years with the continuous development of new methods to enhance the sensitivity, resolution, and speed of data acquisition. Some of the approaches were earlier used for peptide and protein resonance assignments and have now been adapted to metabolomics. At the same time, new NMR methods involving novel data acquisition techniques, suited particularly for high-throughput analysis in metabolomics, have been developed. In this review, we focus on the different sampling strategies or data acquisition methods that have been developed in our laboratory and other groups to acquire NMR spectra rapidly with high sensitivity and resolution for metabolomics. In particular, we focus on the use of multiple receivers, phase modulation NMR spectroscopy, and fast-pulsing methods for identification and assignments of metabolites. © 2020 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Publication:	Magnetic Resonance in Chemistry
Publisher:	John Wiley and Sons Ltd
Additional Information:	Copyright to this article belongs to John Wiley and Sons Ltd
Department/Centre:	Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility)
Date Deposited:	21 Dec 2020 07:02
Last Modified:	21 Dec 2020 07:02
URI:	http://eprints.iisc.ac.in/id/eprint/67219

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