Development of Minimal Diguanosinyl Motif toward RNA G-Quadruplex-Like Structures in Solution

Pal, C and Chakraborty, TK (2020) Development of Minimal Diguanosinyl Motif toward RNA G-Quadruplex-Like Structures in Solution. In: ChemBioChem .

	PDF che_2020.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy
Preview	PDF cbic202000002-sup-0001-misc_information.pdf - Published Supplemental Material Download (1MB) | Preview

Abstract

Among the non-canonical structures of B-DNA, the G-quadruplex is of particular interest because of its well-defined conformation, high stability, and versatility. Herein we report our studies on the development of an amide-linked minimal diguanosinyl motif that forms a G-quadruplex-like structure in solution in the presence of potassium cations; various linear guanosine amino acid dimers were synthesized with linkers of different chain lengths to investigate the optimum flexibility required to form such structures.

Item Type:	Journal Article
Publication:	ChemBioChem
Publisher:	Wiley-VCH Verlag
Additional Information:	The copyright of this article belongs to Wiley-VCH Verlag
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	17 Jun 2020 10:15
Last Modified:	17 Jun 2020 10:15
URI:	http://eprints.iisc.ac.in/id/eprint/64825

Actions (login required)

View Item