Mn(II) complex of a di-2-pyridyl ketone-N(4)-substituted thiosemicarbazone: Versatile biological properties and naked-eye detection of Fe2+ and Ru3+ ions

Amritha, B and Manaf, O and Nethaji, M and Sujith, A and Prathapachandra Kurup, MR and Vasudevan, S (2020) Mn(II) complex of a di-2-pyridyl ketone-N(4)-substituted thiosemicarbazone: Versatile biological properties and naked-eye detection of Fe2+ and Ru3+ ions. In: Polyhedron, 178 .

	PDF pol_178-1_2020.pdf - Published Version Restricted to Registered users only Download (2MB) | Request a copy
	Microsoft Word 1-s2.0-S0277538719307788-mmc1.doc - Published Supplemental Material Download (136kB)
	Archive (ZIP) 1-s2.0-S0277538719307788-mmc2 (1).zip - Published Supplemental Material Download (546kB)

Abstract

A novel manganese(II) complex of a di-2-pyridyl ketone N(4)-phenyl thiosemicarbazone (HL) was synthesized and characterized. Single crystal X-ray diffraction studies revealed that the asymmetric unit of the triclinic unit cell contained two independent Mn(L)2 molecules together with two water molecules of crystallization and a DMF molecule. DNA binding studies of the ligand and its complex were conducted using absorption titrations, fluorescent intercalator displacement assays and viscosity measurements. Both the ligand and the complex were found to show good DNA binding abilities and actively displaced the standard intercalator ethidium bromide. In addition to the DNA binding studies, antimicrobial activities of the compounds were also determined and the complex exhibited higher antibacterial activity compared to the ligand HL. Another interesting property exhibited by the manganese complex was its colorimetric sensing, making it an excellent probe for naked-eye detection of Fe2+ and Ru3+ ions, with a visible color change from yellow to colorless. The recognition ability of the ions by the probe was quantitatively analyzed using a titration ion/complex ratio of 0�2.

Item Type:	Journal Article
Publication:	Polyhedron
Publisher:	Elsevier Ltd
Additional Information:	Copyright of this article belongs to Elsevier Ltd
Keywords:	Mn(II) thiosemicarbazone complex; DNA bindingAntibacterial; Naked-eye detection; Sensing of metal ions
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	29 Jan 2020 06:11
Last Modified:	29 Jan 2020 06:11
URI:	http://eprints.iisc.ac.in/id/eprint/64393

Actions (login required)

View Item