Roy, S S and Rayner, P J and Burns, M J and Duckett, S B (2020) A simple and cost-efficient technique to generate hyperpolarized long-lived 15N-15N nuclear spin order in a diazine by signal amplification by reversible exchange. In: Journal of Chemical Physics, 152 (1).
|
PDF
jou_che_phy_152-1_2020.pdf - Published Version Download (1MB) | Preview |
Abstract
Signal Amplification by Reversible Exchange (SABRE) is an inexpensive and simple hyperpolarization technique that is capable of boosting nuclear magnetic resonance sensitivity by several orders of magnitude. It utilizes the reversible binding of para-hydrogen, as hydride ligands, and a substrate of interest to a metal catalyst to allow for polarization transfer from para-hydrogen into substrate nuclear spins. While the resulting nuclear spin populations can be dramatically larger than those normally created, their lifetime sets a strict upper limit on the experimental timeframe. Consequently, short nuclear spin lifetimes are a challenge for hyperpolarized metabolic imaging. In this report, we demonstrate how both hyperpolarization and long nuclear spin lifetime can be simultaneously achieved in nitrogen-15 containing derivatives of pyridazine and phthalazine by SABRE. These substrates were chosen to reflect two distinct classes of 15N2-coupled species that differ according to their chemical symmetry and thereby achieve different nuclear spin lifetimes. The pyridazine derivative proves to exhibit a signal lifetime of �2.5 min and can be produced with a signal enhancement of �2700. In contrast, while the phthalazine derivative yields a superior 15 000-fold 15N signal enhancement at 11.7 T, it has a much shorter signal lifetime.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Chemical Physics |
| Publisher: | American Institute of Physics Inc. |
| Additional Information: | Copyright of this article belongs to American Institute of Physics Inc. |
| Keywords: | Catalysts; Pyridine; Signal processing; Substrates, Hyperpolarization; Metabolic imaging; Nuclear spin order; Orders of magnitude; Polarization transfer; Reversible binding; Signal amplifications; Signal enhancement, Spin dynamics |
| Department/Centre: | Division of Chemical Sciences > Inorganic & Physical Chemistry |
| Date Deposited: | 22 Jan 2020 10:05 |
| Last Modified: | 22 Jan 2020 10:05 |
| URI: | http://eprints.iisc.ac.in/id/eprint/64357 |
Actions (login required)
 |
View Item |
