Natural tripeptide capped pH-sensitive gold nanoparticles for efficacious doxorubicin delivery both: In vitro and in vivo

Kumar, K and Moitra, P and Bashir, M and Kondaiah, P and Bhattacharya, S (2020) Natural tripeptide capped pH-sensitive gold nanoparticles for efficacious doxorubicin delivery both: In vitro and in vivo. In: Nanoscale, 12 (2). pp. 1067-1074.

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Abstract

Nanobiotechnology has been gaining ever-increasing interest for the successful implementation of chemotherapy based treatment of cancer. Gold nanoparticles (AuNPs) capped with a natural pH-responsive short tripeptide (Lys-Phe-Gly or KFG) sequence are presented herein for significant intracellular delivery of an anti-cancer drug, doxorubicin (DOX). A particularly increased apoptotic response has been observed for DOX treatments mediated by KFG-AuNPs when compared with drug alone treatments in various cell lines (BT-474, HeLa, HEK 293 T and U251). Furthermore, KFG-AuNP mediated DOX treatment significantly decreases cell proliferation and tumor growth in a BT-474 cell xenograft model in nude mice. In addition, KFG-AuNPs demonstrate efficacious drug delivery in DOX-resistant HeLa cells (HeLa-DOXR). .

Item Type:	Journal Article
Publication:	Nanoscale
Publisher:	The Royal Society of Chemistry
Additional Information:	copyright for this article belongs to The Royal Society of Chemistry
Keywords:	Cell culture; Cell proliferation; Chemotherapy; Controlled drug delivery; Diseases; Fiber optic sensors; Gold nanoparticles; Lanthanum compounds; Mammals; Metal nanoparticles, Anticancer drug; Apoptotic response; Cell lines; Doxorubicin; Intracellular delivery; pH sensitive; PH-responsive; Tumor growth, Targeted drug delivery
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Chemical Sciences > Organic Chemistry
Date Deposited:	20 Jan 2020 11:42
Last Modified:	20 Jan 2020 11:42
URI:	http://eprints.iisc.ac.in/id/eprint/64356

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