Mn(I)-based photoCORMs for trackable, visible light-induced CO release and photocytotoxicity to cancer cells

Musib, Dula and Raza, Md Kausar and Martina, Kh and Roy, Mithun (2019) Mn(I)-based photoCORMs for trackable, visible light-induced CO release and photocytotoxicity to cancer cells. In: POLYHEDRON, 172 . pp. 125-131.

	PDF Pol_172_125-131_2019.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy
Preview	PDF 1-s2.0-S0277538719302475-mmc1.pdf - Published Supplemental Material Download (3MB) | Preview

Abstract

Four new Mn(l)-carbonyl complexes of general formula, Mn(L)(CO)(3)] (1 4) where L = 2-(benzod] thiazol-2-yl)phenol (L-1), 2-(benzod]thiazol-2-yl)-4,6-di-tert-butylphenol (L-2), 2-(2-hydroxyphenyl)-3H-anthra1,2-d]imidazole-6,11-dione (L-3) and 2-(3,5-di-tert-butyl-2-hydroxyphenyl)-3H-anthra1,2-d] imidazole-6,11-dione (L-4) rapidly release CO cooperatively on activation with visible light accompanied by a visual change in luminescence properties of the complexes allowing us to track photo-activated CO release in HeLa cells. CO-induced photocytotoxicity by the complexes was also studied in HeLa cells. Photo-activated CO release and mechanism was spectroscopically and theoretically probed. Overall, Mn(I)-carbonyls with theranostics properties are potentially emerged as the next-generation phototheranostics.

Item Type:	Journal Article
Publication:	POLYHEDRON
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Additional Information:	Copyright for this article belongs to Elsevier.
Keywords:	Mn(I)-based theranostic photoCORMs; Cooperative CO release; Visible light-induced cytotoxicity; DFT and TD-DFT calculations; TURN-ON fluorescence
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	17 Jan 2020 11:40
Last Modified:	17 Jan 2020 11:40
URI:	http://eprints.iisc.ac.in/id/eprint/64120

Actions (login required)

View Item