MoS2-Modified Curcumin Nanostructures: The Novel Theranostic Hybrid Having Potent Antibacterial and Antibiofilm Activities against Multidrug-Resistant Hypervirulent Klebsiella pneumoniae

Singh, Ashish Kumar and Mishra, Himanshu and Firdaus, Zeba and Yadav, Shivangi and Aditi, Prerana and Nandy, Nabarun and Sharma, Kavyanjali and Bose, Priyanka and Pandey, Akhilesh Kumar and Chauhan, Brijesh Singh and Neogi, Kaushik and Vikram, Kunwar and Srivastava, Anchal and Kar, Amrita Ghosh and Prakash, Pradyot (2019) MoS2-Modified Curcumin Nanostructures: The Novel Theranostic Hybrid Having Potent Antibacterial and Antibiofilm Activities against Multidrug-Resistant Hypervirulent Klebsiella pneumoniae. In: CHEMICAL RESEARCH IN TOXICOLOGY, 32 (8). pp. 1599-1618.

Preview	PDF che_res_tox_32-8_1599_2019.pdf - Published Version Download (3MB) | Preview
	PDF tx9b00135_si_001.pdf - Published Supplemental Material Download (1MB)

Abstract

The recent emergence of hypervirulent clinical variants of Klebsiella pneumoniae (hvKP) causing community-acquired, invasive, metastatic, life-threatening infections of lungs, pleura, prostate, bones, joints, kidneys, spleen, muscles, soft-tissues, skin, eyes, central nervous system (CNS) including extrahepatic abscesses, and primary bacteremia even in healthy individuals has posed stern challenges before the existing treatment modalities. There is therefore an urgent need to look for specific and effective therapeutic alternatives against the said bacterial infection or recurrence. A new type of MoS2-modified curcumin nanostructure has been developed and evaluated as a potential alternative for the treatment of multidrug-resistant isolates. The curcumin quantum particles have been fabricated with MoS2 via a seed-mediated hydrothermal method, and the resulting MoS2-modified curcumin nanostructures (MQCs) have been subsequently tested for their antibacterial and antibiofilm properties against hypervirulent multidrug-resistant Klebsiella pneumoniae isolates. In the present study, we found MQCs inhibiting the bacterial growth at a minimal concentration of 0.0156 mu g/mL, while complete inhibition of bacterial growth was evinced at concentration 0.125 mu g/mL. Besides, we also investigated their biocompatibility both in vitro and in vivo. MQCs were found to be nontoxic to the SiHa cells at a dose as high as 1024 mu g/mL on the basis of the tested adhesion, spreading of the cells, and also on the various serological, biochemical, and histological investigations of the vital organs and blood of the Charles Foster Rat. These results suggest that MQCs have potent antimicrobial activities against hvKP and other drug resistant isolates and therefore may be used as broad spectrum antibacterial and antibiofilm agents.

Item Type:	Journal Article
Publication:	CHEMICAL RESEARCH IN TOXICOLOGY
Publisher:	AMER CHEMICAL SOC
Additional Information:	Copyright of this article belongs to AMER CHEMICAL SOC
Keywords:	QUANTUM DOTS; TIO2 NANOPARTICLES; LIPID ASYMMETRY; VIRULENCE; MEMBRANES; TOXICITY; GOMPERTZ; BIOLOGY; BIOFILM; SILVER
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	20 Nov 2019 11:37
Last Modified:	20 Nov 2019 11:37
URI:	http://eprints.iisc.ac.in/id/eprint/63607

Actions (login required)

View Item