Hyperpolarising Pyruvate through Signal Amplification by Reversible Exchange (SABRE)

Iali, Wissam and Roy, Soumya S and Tickner, Ben J and Ahwal, Fadi and Kennerley, Aneurin J and Duckett, Simon B (2019) Hyperpolarising Pyruvate through Signal Amplification by Reversible Exchange (SABRE). In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58 (30). pp. 10271-10275.

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Abstract

Hyperpolarisation methods that premagnetise agents such as pyruvate are currently receiving significant attention because they produce sensitivity gains that allow disease tracking and interrogation of cellular metabolism by magnetic resonance. Here, we communicate how signal amplification by reversible exchange (SABRE) can provide strong C-13 pyruvate signal enhancements in seconds through the formation of the novel polarisation transfer catalyst Ir(H)(2)(eta(2)-pyruvate)(DMSO)(IMes)]. By harnessing SABRE, strong signals for 1-C-13]- and 2-C-13]pyruvate in addition to a long-lived singlet state in the 1,2-C-13(2)] form are readily created; the latter can be observed five minutes after the initial hyperpolarisation step. We also demonstrate how this development may help with future studies of chemical reactivity.

Item Type:	Journal Article
Publication:	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Publisher:	WILEY-V C H VERLAG GMBH
Additional Information:	copyright for this article belongs to WILEY-V C H VERLAG GMBH
Keywords:	catalysis; hyperpolarization; pyruvate; SABRE; singlet state
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	07 Aug 2019 08:07
Last Modified:	07 Aug 2019 08:07
URI:	http://eprints.iisc.ac.in/id/eprint/63362

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