RGG-motif self-association regulates eIF4G-binding translation repressor protein Scd6

Poornima, Gopalakrishna and Mythili, Ravishankar and Nag, Priyabrata and Parbin, Sabnam and Verma, Praveen Kumar and Hussain, Tanweer and Rajyaguru, Purusharth I (2019) RGG-motif self-association regulates eIF4G-binding translation repressor protein Scd6. In: RNA BIOLOGY, 16 (9). pp. 1215-1227.

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Abstract

Regulation of mRNA translation plays a key role in the control of gene expression. Scd6, a conserved RGG-motif containing protein represses translation by binding to translation initiation factor eIF4G1. Here we report that Scd6 binds itself in RGG-motif dependent manner and self-association regulates its repression activity. Scd6 self-interaction competes with eIF4G1 binding and methylation of Scd6 RGG-motif by Hmt1 negatively affects self-association. Results pertaining to Sbp1 indicate that self-association could be a general feature of RGG-motif containing translation repressor proteins. Taken together, our study reveals a mechanism of regulation of eIF4G-binding RGG-motif translation repressors.

Item Type:	Journal Article
Publication:	RNA BIOLOGY
Publisher:	TAYLOR & FRANCIS INC
Additional Information:	copyright for this article belongs to TAYLOR & FRANCIS INC
Department/Centre:	Division of Biological Sciences > Biochemistry Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	13 Sep 2019 10:26
Last Modified:	13 Sep 2019 10:26
URI:	http://eprints.iisc.ac.in/id/eprint/63184

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