Saha, Prasenjit Prasad and Vishwanathan, Vinaya and Bankapalli, Kondalarao and D'Silva, Patrick (2018) Iron-Sulfur Protein Assembly in Human Cells. [Book Chapter]
Full text not available from this repository.Abstract
Iron-sulfur (Fe-S) clusters serve as a fundamental inorganic constituent of living cells ranging from bacteria to human. The importance of Fe-S clusters is underscored by their requirement as a co-factor for the functioning of different enzymes and proteins. The biogenesis of Fe-S cluster is a highly coordinated process which requires specialized cellular machinery. Presently, understanding of Fe-S cluster biogenesis in human draws meticulous attention since defects in the biogenesis process result in development of multiple diseases with unresolved solutions. Mitochondrion is the major cellular compartment of Fe-S cluster biogenesis, although cytosolic biogenesis machinery has been reported in eukaryotes, including in human. The core biogenesis pathway comprises two steps. The process initiates with the assembly of Fe-S cluster on a platform scaffold protein in the presence of iron and sulfur donor proteins. Subsequent process is the transfer and maturation of the cluster to a bonafide target protein. Human Fe-S cluster biogenesis machinery comprises the mitochondrial iron-sulfur cluster (ISC) assembly and export system along with the cytosolic Fe-S cluster assembly (CIA) machinery. Impairment in the Fe-S cluster machinery components results in cellular dysfunction leading to various mitochondrial pathophysiological consequences. The current review highlights recent developments and understanding in the domain of Fe-S cluster assembly biology in higher eukaryotes, particularly in human cells.
| Item Type: | Book Chapter |
|---|---|
| Series.: | Reviews of Physiology Biochemistry and Pharmacology |
| Publisher: | SPRINGER-VERLAG BERLIN |
| Additional Information: | Copyright of this article belongs to Reviews of Physiology Biochemistry and Pharmacology |
| Keywords: | Chaperones; Fe-S biogenesis; Iron-sulfur clusters; Iron-transfer; Mitochondria |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 22 Feb 2019 05:15 |
| Last Modified: | 22 Feb 2019 05:15 |
| URI: | http://eprints.iisc.ac.in/id/eprint/61782 |
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