Curcumin nanoconjugate inhibits aggregation of N-terminal region (A beta-16) of an amyloid beta peptide

Brahmkhatri, Varsha P and Sharma, Naveen and Sunanda, Punnepalli and D'Souza, Aviva and Raghothama, Srinivasarao and Atreya, Hanudatta S (2018) Curcumin nanoconjugate inhibits aggregation of N-terminal region (A beta-16) of an amyloid beta peptide. In: NEW JOURNAL OF CHEMISTRY, 42 (24). pp. 19881-19892.

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Abstract

The present study describes a curcumin nanoformulation that inhibits amyloid beta (A beta) aggregation. Curcumin is well known for its anti-carcinogenic, antioxidant and anti-inflammatory properties. Recent studies have shown that curcumin also possesses neuroprotective and cognitive-enhancing properties that may help to delay or prevent amyloid beta aggregation in Alzheimer's disease. However, due to the poor aqueous solubility and bioavailability of curcumin, its clinical applications are limited. To increase the bioavailability of curcumin, a highly stable and completely water soluble system consisting of a polymeric nanoparticle-encapsulated curcumin conjugate with gold nanoparticles decorated on the surface (PVP-C-AuNP) was formulated. The curcumin nano-conjugates were characterized by various physical, chemical and spectroscopic techniques including UV-visible spectroscopy, FT-IR spectroscopy, DLS and zeta potential analysis. The surface morphology of the conjugates was studied using TEM. Though the aggregation properties of full-length A beta 42 have been explored in detail, a shorter A beta fragment from the N-terminal region of the peptide, A beta 1-16, was chosen for the current study as it demonstrates seeding properties for aggregate formation in the healthy brain. The aggregation kinetics of A beta 1-16 was studied using NMR spectroscopy and TEM. The fabricated curcumin nanoformulations were not only found to inhibit A beta 1-16 aggregation but they also disintegrated already formed aggregates.

Item Type:	Journal Article
Publication:	NEW JOURNAL OF CHEMISTRY
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	Copyright of this article belongs to ROYAL SOC CHEMISTRY
Department/Centre:	Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility)
Date Deposited:	15 Feb 2019 09:00
Last Modified:	15 Feb 2019 09:00
URI:	http://eprints.iisc.ac.in/id/eprint/61725

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