Multi-scale surface topography to minimize adherence and viability of nosocomial drug-resistant bacteria

Hasan, Jafar and Jain, Shubham and Padmarajan, Rinsha and Purighalla, Swathi and Sambandamurthy, Vasan K and Chatterjee, Kaushik (2018) Multi-scale surface topography to minimize adherence and viability of nosocomial drug-resistant bacteria. In: MATERIALS & DESIGN, 140 . pp. 332-344.

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Abstract

Toward minimizing bacterial colonization of surfaces, we present a one-step etching technique that renders aluminumalloys withmicro-and nano-scale roughness. Such amulti-scale surface topography exhibited enhanced antibacterial effect against awide range of pathogens. Multi-scale topography of commercially grade pure aluminumkilled 97% of Escherichia coli and 28% of Staphylococcus aureus cells in comparison to 7% and 3%, respectively, on the smooth surfaces. Multi-scale topography on Al 5052 surfacewas shown to kill 94% of adhered E. coli cells. Themicroscale features on the etched Al 1200 alloy were not found to be significantly bactericidal, but shown to decrease the adherence of S. aureus cells by one-third. The fabricationmethod is easily scalable for industrial applications. Analysis of roughness parameters determined by atomic forcemicroscopy revealed a set of significant parameters that can yield a highly bactericidal surface; thereby providing the design to make any surface bactericidal irrespective of the method of fabrication. The multi-scale roughness of Al 5052 alloy was also highly bactericidal to nosocomial isolates of E. coli, K. pneumoniae and P. aeruginosa. We envisage the potential application of engineered surfaces with multi-scale topography to minimize the spread of nosocomial infections. (C) 2017 The Author(s). Published by Elsevier Ltd.

Item Type:	Journal Article
Publication:	MATERIALS & DESIGN
Publisher:	ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
Additional Information:	Copy right for the article belong to ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	08 Mar 2018 19:08
Last Modified:	08 Mar 2018 19:08
URI:	http://eprints.iisc.ac.in/id/eprint/59118

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