Enantioselective dearomatization of isoquinolines by anion-binding catalysis en route to cyclic alpha-aminophosphonates

Choudhury, Abhijnan Ray and Mukherjee, Santanu (2016) Enantioselective dearomatization of isoquinolines by anion-binding catalysis en route to cyclic alpha-aminophosphonates. In: CHEMICAL SCIENCE, 7 (12). pp. 6940-6945.

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Abstract

An enantioselective dearomatization of isoquinolines has been developed using chiral anion-binding catalysis. This transformation, catalyzed by a simple and easy to prepare tert-leucine-based thiourea derivative, makes use of silyl phosphite as a nucleophile and generates cyclic alpha-aminophosphonates. This is the first time asymmetric anion-binding catalysis has been applied to the synthesis of alpha-aminophosphonates.

Item Type:	Journal Article
Publication:	CHEMICAL SCIENCE
Additional Information:	Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	09 Feb 2017 07:16
Last Modified:	09 Feb 2017 07:16
URI:	http://eprints.iisc.ac.in/id/eprint/56226

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