Pluronic copolymer encapsulated SCR7 as a potential anticancer agent

John, Franklin and George, Jinu and Srivastava, Mrinal and Hassan, PA and Aswal, VK and Karkie, Subhas S and Raghavan, Sathees C (2015) Pluronic copolymer encapsulated SCR7 as a potential anticancer agent. In: FARADAY DISCUSSIONS, 177 . pp. 155-161.

PDF far_dis-177_155_2015.pdf - Published Version Restricted to Registered users only Download (402kB) | Request a copy

Abstract

Nonhomologous end joining (NHEJ) of DNA double strand breaks (DSBs) inside cells can be selectively inhibited by 5,6-bis-(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) which possesses anticancer properties. The hydrophobicity of SCR7 decreases its bioavailability which is a major setback in the utilization of this compound as a therapeutic agent. In order to circumvent the drawback of SCR7, we prepared a polymer encapsulated form of SCR7. The physical interaction of SCR7 and Pluronic (R) copolymer is evident from different analytical techniques. The in vitro cytotoxicity of the drug formulations is established using the MTT assay.

Item Type:	Journal Article
Publication:	FARADAY DISCUSSIONS
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Keywords:	STRAND BREAK REPAIR; CHROMOSOMAL TRANSLOCATIONS; CANCER; DRUG
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	22 May 2015 07:51
Last Modified:	22 May 2015 07:51
URI:	http://eprints.iisc.ac.in/id/eprint/51579

Actions (login required)

View Item