Venkatesha, N and Poojar, Pavan and Qurishi, Yasrib and Geethanath, Sairam and Srivastava, Chandan (2015) Graphene oxide-Fe3O4 nanoparticle composite with high transverse proton relaxivity value for magnetic resonance imaging. In: JOURNAL OF APPLIED PHYSICS, 117 (15).
![]() |
PDF
jou_app_phy-117_15_2015.pdf - Published Version Restricted to Registered users only Download (2MB) | Request a copy |
Abstract
The potential of graphene oxide-Fe3O4 nanoparticle (GO-Fe3O4) composite as an image contrast enhancing material in magnetic resonance imaging has been investigated. Proton relaxivity values were obtained in three different homogeneous dispersions of GO-Fe3O4 composites synthesized by precipitating Fe3O4 nanoparticles in three different reaction mixtures containing 0.01 g, 0.1 g, and 0.2 g of graphene oxide. A noticeable difference in proton relaxivity values was observed between the three cases. A comprehensive structural and magnetic characterization revealed discrete differences in the extent of reduction of the graphene oxide and spacing between the graphene oxide sheets in the three composites. The GO-Fe3O4 composite framework that contained graphene oxide with least extent of reduction of the carboxyl groups and largest spacing between the graphene oxide sheets provided the optimum structure for yielding a very high transverse proton relaxivity value. It was found that the GO-Fe3O4 composites possessed good biocompatibility with normal cell lines, whereas they exhibited considerable toxicity towards breast cancer cells. (C) 2015 AIP Publishing LLC.
Item Type: | Journal Article |
---|---|
Publication: | JOURNAL OF APPLIED PHYSICS |
Publisher: | AMER INST PHYSICS |
Additional Information: | Copy right for this article belongs to the AMER INST PHYSICS, 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA |
Keywords: | MRI CONTRAST AGENTS; IRON-OXIDE NANOPARTICLES; FE3O4 NANOPARTICLES; FERRITE NANOPARTICLES; WATER EXCHANGE; PARTICLE-SIZE |
Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy) |
Date Deposited: | 22 May 2015 07:25 |
Last Modified: | 22 May 2015 07:25 |
URI: | http://eprints.iisc.ac.in/id/eprint/51561 |
Actions (login required)
![]() |
View Item |