Zaveri, Anisha and Visweswariah, Sandhya S (2013) Cyclic AMP in Mycobacteria: the second messenger comes first. In: CURRENT SCIENCE, 105 (5). pp. 666-675.
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Abstract
Cyclic AMP (cAMP) has emerged as a pivotal molecule for signalling in all life forms. Mycobacterial genomes have been found to encode for numerous proteins that are involved in cAMP generation, degradation and utilization. Many of these proteins have domain organizations unique to mycobacteria. This review summarizes recent advances in mechanisms of cAMP synthesis and degradation, focusing on the processes by which cAMP modulates mycobacterial signalling. We explore its impact on the physiology of the organism and on the discourse between M. tuberculosis and its host.
| Item Type: | Journal Article |
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| Publication: | CURRENT SCIENCE |
| Publisher: | INDIAN ACAD SCIENCES |
| Additional Information: | copyright for this article belongs to INDIAN ACAD SCIENCES |
| Keywords: | Adenylyl cyclase; cyclic nucleotide binding protein; cyclic AMP; mycobacteria; phosphodiesterase |
| Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics |
| Date Deposited: | 26 Nov 2013 15:23 |
| Last Modified: | 26 Nov 2013 15:27 |
| URI: | http://eprints.iisc.ac.in/id/eprint/47797 |
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