Photoactivated DNA cleavage and anticancer activity of oxovanadium(IV) complexes of curcumin

Balaji, Babu and Somyajit, Kumar and Banik, Bhabatosh and Nagaraju, Ganesh and Chakravarty, Akhil R (2013) Photoactivated DNA cleavage and anticancer activity of oxovanadium(IV) complexes of curcumin. In: Inorganica Chimica Acta, 400 . pp. 142-150.

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Abstract

Oxovanadi um(IV) complexes VO(Fc-pic)(acac)](ClO4) (1), VO(Fc-pic)(cur)](ClO4) (2), VO(Ph-pic)(acac)](ClO4) (3) and VO(Ph-pic)(cur)](ClO4) (4), where Fc-pic and Ph-pic are ferrocenylmethyl-bis-(2-pyridylmethylamine) (in 1, 2) and bis-(2-pyridylmethyl)benzylamine (in 3, 4), respectively, acac is acetylacetonate anion (in 1, 3) and cur is curcumin anion (in 2, 4) were prepared, characterized and their photo-induced DNA cleavage and anticancer activity studied. The crystal structure of 1 as its PF6 salt (1a) shows the presence of a VO2+ moiety in VO3N3 coordination geometry. The complexes show a d-d band at similar to 790 nm in DMF and display V(IV)/V(III) redox couple near -1.45 V vs. SCE in DMF-0.1 M TBAP. The complexes are avid binders to calf thymus DNA. Complex 2 efficiently photo-cleaves plasmid DNA in near-IR light of 785 nm forming (OH)-O-center dot radicals. The curcumin complexes show photocytotoxicity in HeLa cancer cells in visible light of 400-700 nm with significant cellular uptake within 4 h of incubation time.

Item Type:	Journal Article
Publication:	Inorganica Chimica Acta
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Oxovanadium(IV) Complex; Curcumin; Ferrocene; Crystal Structure; DNA Photocleavage; Photocytotoxicity
Department/Centre:	Division of Biological Sciences > Biochemistry Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	23 Jun 2013 09:41
Last Modified:	23 Jun 2013 09:41
URI:	http://eprints.iisc.ac.in/id/eprint/46756

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