Rajbongshi, Basanta Kumar and Nair, Nisanth N and Nethaji, M and Ramanathan, Gurunath (2012) Segregation into Chiral Enantiomeric Conformations of an Achiral Molecule by Concomitant Polymorphism. In: Crystal Growth & Design, 12 (4). pp. 1823-1829.
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Abstract
An analogue of the green fluorescent protein (GFP) luminophore crystallizes from a methanol solution impregnated with dichloromethane, into a pair of chiral crystals. Thermal analysis, fluorescence emission studies, and crystal packing analysis show that the two crystals are different materials. The two polymorphs arise from the rotation of a monosubstituted benzene ring about a C-N bond which results in the formation of two strong bifurcated C-H center dot center dot center dot O intermolecular bonds to oxygen O(6). The color difference has been ascribed to a difference in the packing of the two crystal forms. Theoretical studies supported by low temperature NMR show low kinetic energy barriers (similar to 10 kJ mol(-1)) separating the asymmetric units of the two crystal structures, suggesting that the driving force for the polymorphism could be the result of packing of two different asymmetric units.
Item Type: | Journal Article |
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Publication: | Crystal Growth & Design |
Publisher: | American Chemical Society |
Additional Information: | Copyright of this article is belongs to American Chemical Society. |
Keywords: | GREEN FLUORESCENT PROTEIN;CRYSTAL-STRUCTURES;4,4-DIPHENYL-2,5-CYCLOHEXADIENONE |
Department/Centre: | Division of Chemical Sciences > Inorganic & Physical Chemistry |
Date Deposited: | 14 Aug 2012 05:37 |
Last Modified: | 14 Aug 2012 05:41 |
URI: | http://eprints.iisc.ac.in/id/eprint/44496 |
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