Pasupuleti, Sasikiran and Avadanam, Anusha and Madras, Giridhar (2011) Synthesis, Characterization, and Degradation of Biodegradable Poly(mannitol citric dicarboxylate) Copolyesters. In: Polymer Engineering & Science, 51 (10, SI). pp. 2035-2043.
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Three groups of poly(mannitol citric dicarboxylate) [p(MCD)] copolyesters were synthesized by catalyst-free melt condensation of mannitol with acids. The resulting copolyesters were designated as poly(mannitol citric succinate) [p(MCSu)], poly(mannitol citric adipate) [p(MCA)], poly(mannitol citric sebacate) [p(MCS)]. The polymers were characterized by FTIR, (1)H NMR, and DSC analysis. The synthesized p(MCD) polymers exhibit glass transition temperatures ranging from 16.5 to 58.58 degrees C. The mechanical, degradation properties, and the drug-releasing characteristics of these polymers were investigated. It was observed that the mechanical properties of the p(MCD) polymers cover a wide range with Young's modulus of the polymer varying from 12.25 to 660 MPa. Hydrolytic degradation of all polymers was investigated by incubating polymer discs in PBS and the hydrolytic degradation of p(MCD) polymers followed the order, p(MCSu) > p(MCA) > p(MCS). This was attributed to the number of -CH(2)(units in the dicarboxylic monomers. The release of model drug compounds from the p(MCD) polymer discs was also studied. POLYM. ENG. SCI., 51:2035-2043, 2011. (C) 2011 Society of Plastics Engineers
| Item Type: | Journal Article |
|---|---|
| Publication: | Polymer Engineering & Science |
| Publisher: | John Wiley & Sons |
| Additional Information: | Copyright of this article belongs to John Wiley & Sons. |
| Department/Centre: | Division of Mechanical Sciences > Chemical Engineering |
| Date Deposited: | 08 Nov 2011 11:48 |
| Last Modified: | 08 Nov 2011 11:48 |
| URI: | http://eprints.iisc.ac.in/id/eprint/41933 |
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