Synthesis and Degradation of Sorbitol-Based Polymers

Pasupuleti, Sasikiran and Madras, Giridhar (2011) Synthesis and Degradation of Sorbitol-Based Polymers. In: Journal of Applied Polymer Science, 121 (5). pp. 2861-2869.

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Abstract

A new class of biodegradable copolyesters was synthesized by the catalyst-free melt condensation of sorbitol with citric acid, tartaric acid, and sebacic acid. The resulting polymers were designated as poly(sorbitol citric sebacate) p(SCS)] and poly(sorbitol tartaric sebacate) p(STS)]. The synthesized polymers were characterized by Fourier transform infrared spectroscopy, H-1-NMR spectroscopy, and differential scanning calorimetry analysis. Porous spongelike scaffolds were prepared with a salt-leaching technique and characterized with scanning electron microscopy. Tensile testing of the p(SCS) and p(STS) polymers showed that they exhibited a wide range of mechanical properties. The Young's modulus and tensile strengths of the polymers ranged from 1.06 +/- 0.12 to 462.65 +/- 34.21 MPa and from 0.45 +/- 0.04 to 20.32 +/- 2.54 MPa, respectively. In vitro degradation studies were performed on disc-shaped polymer samples. The half-life of the polymers ranged from 0.54 to 38.52 days. The percentage hydration of the polymers was in the range 9.36 +/- 1.26 to 78.25 +/- 1.91, with sol contents of 2-14%. At any given polymer composition, the Young's modulus and tensile strength of p(SCS) was higher than that of p(STS), whereas the degradation rates of p(SCS) was lower than that of p(STS). This was attributed to the structural difference between the citric and tartaric monomers and to the degree of crosslinking. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121: 2861-2869, 2011

Item Type:	Journal Article
Publication:	Journal of Applied Polymer Science
Publisher:	John Wiley and Sons
Additional Information:	Copyright of this article belongs to John Wiley and Sons.
Keywords:	biocompatibility;biomaterials;strength
Department/Centre:	Division of Mechanical Sciences > Chemical Engineering
Date Deposited:	04 Jul 2011 08:11
Last Modified:	04 Jul 2011 08:11
URI:	http://eprints.iisc.ac.in/id/eprint/38881

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