Prakash, N and Narayanan, K and Murthy, GS and Moudgal, NR and Honnegowda, * (1992) The effect of malathion, an organophosphate, on the plasma FSH, 17 beta-estradiol and progesterone concentrations and acetylcholinesterase activity and conception in dairy cattle. In: Veterinary & Human Toxicology, 34 (2). pp. 116-119.
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The effect of malathion on jugular plasma concentrations of follicle-stimulating hormone (FSH), estradiol (E2), progesterone (P4) and acetylcholinesterase (AchE) on conception in dairy cattle during a cloprostenol (prostaglandin F2-alpha analogue, PG)-induced estrus was studied. Malathion (1 mg/kg, intraruminally) given at the onset of estrus (48 h after PG) did not alter the plasma FSH or E2 concentrations but significantly (P < 0.05) inhibited plasma P4 concentration. The mean P4 concentration in the malathion-treated group on days 8 and 12 were 0.8 +/- 0.4 and 1.0 +/- 0.5 ng/ml, as compared to 2.6 +/- 0.0 and 2.4 +/- 0.3 ng/ml in the control group. There was a nonsignificant (P > 0.05) inhibition of plasma AchE activity in malathion-treated cattle. Conception was 16.6% in malathion-treated cows and 50% in controls. Inhibition of progesterone secretion and poor conception occurred after the single intraruminal dose of malathion at the onset of estrus.
Item Type: | Journal Article |
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Publication: | Veterinary & Human Toxicology |
Publisher: | Comparative Toxicology Lab |
Additional Information: | Copyright of this article belongs to Comparative Toxicology Lab. |
Department/Centre: | Division of Biological Sciences > Central Animal Facility (Formerly Primate Research Laboratory) |
Date Deposited: | 30 May 2011 05:50 |
Last Modified: | 30 May 2011 05:50 |
URI: | http://eprints.iisc.ac.in/id/eprint/37767 |
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