Enantioselective total synthesis of bioactive natural product (+)-Sch642305: a structurally novel inhibitor of bacterial DNA primase and HIV-1 Tat transactivation

Mehta, Goverdhan and Shinde, Harish M (2005) Enantioselective total synthesis of bioactive natural product (+)-Sch642305: a structurally novel inhibitor of bacterial DNA primase and HIV-1 Tat transactivation. In: Chemical Communications (29). pp. 3703-3705.

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Abstract

The total synthesis of the bioactive natural product (+)-Sch 642305 has been achieved from a readily available chiral building block using an RCM protocol to construct the key decalactone moiety; our approach is notable for its built-in flexibility and is diversity oriented.

Item Type:	Journal Article
Publication:	Chemical Communications
Publisher:	Royal Society of Chemistry
Additional Information:	Copyright for this article belongs to Royal Society of Chemistry.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	24 Aug 2005
Last Modified:	19 Sep 2010 04:19
URI:	http://eprints.iisc.ac.in/id/eprint/3552

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