Stability of synchronization in a multi-cellular system

Ghosh, Suma and Rangarajan, Govindan and Sinha, Somdatta (2010) Stability of synchronization in a multi-cellular system. In: EPL: Europhysics Letters, 92 (4).

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Abstract

Networks of biochemical reactions regulated by positive-and negative-feedback processes underlie functional dynamics in single cells. Synchronization of dynamics in the constituent cells is a hallmark of collective behavior in multi-cellular biological systems. Stability of the synchronized state is required for robust functioning of the multi-cell system in the face of noise and perturbation. Yet, the ability to respond to signals and change functional dynamics are also important features during development, disease, and evolution in living systems. In this paper, using a coupled multi-cell system model, we investigate the role of system size, coupling strength and its topology on the synchronization of the collective dynamics and its stability. Even though different coupling topologies lead to synchronization of collective dynamics, diffusive coupling through the end product of the pathway does not confer stability to the synchronized state. The results are discussed with a view to their prevalence in biological systems. Copyright (C) EPLA, 2010

Item Type:	Journal Article
Publication:	EPL: Europhysics Letters
Publisher:	EDP Sciences
Additional Information:	Copyright of this article belongs to EDP Sciences.
Department/Centre:	Division of Physical & Mathematical Sciences > Mathematics
Date Deposited:	31 Jan 2011 09:32
Last Modified:	31 Jan 2011 09:32
URI:	http://eprints.iisc.ac.in/id/eprint/35307

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