Bhat, Charavu Shama and Ramasarma, T (1979) Effect of phenyl and phenolic acids on mevalonate-5-Phosphate decarboxylase if the brain. In: Journal of Neurochemistry, 32 (5). pp. 1531-1537.
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Phenyl and phenolic acids are known to inhibit metabolism of mevalonate in rat brain. The site of inhibition has been found to be mevalonate-5-pyrophosphate decarboxylase. Phenolic acids also inhibited mevalonate-5-phosphate kinase on preincubation. The kinetics showed that p-coumaric acid and isoferulic acid were competing with substrates, mevalonate-5-phosphate or mevalonate-5-pyre phosphate, whereas others showed an uncompetitive type of inhibition. Chlorophenoxyisobutyrate, a hypocholesterolaemic drug, had no effect on these enzymes. An improved method for the synthesis of mevalonate-5-phosphate and mevalonate-5-pyrophosphate, labeled at carbon-1, is described.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Neurochemistry |
| Publisher: | John Wiley and Sons |
| Additional Information: | Copyright of this article belongs to John Wiley and Sons. |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 19 Oct 2010 07:10 |
| Last Modified: | 19 Oct 2010 07:10 |
| URI: | http://eprints.iisc.ac.in/id/eprint/33303 |
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