Bhat , Krishna M and Cama, HR (1978) Thyroidal control of hepatic release and metabolism of vitamin A. In: Biochimica et Biophysica Acta (BBA), 541 (2). pp. 211-222.
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Abstract
The inverse relationship that exists between thyroxine and the vitamin A level of plasma has been examined in chicken. Thyroxine treatment leads to a decrease in the level of vitamin A carrier proteins, retinol-binding protein and prealbumin-2 in plasma and liver. There is an accumulation of vitamin A in the liver, with a greater proportion of vitamin A alcohol being present compared to that of control birds. In thyroxine treatment there is enhanced plasma turnover of retinol-binding protein and prealbumin-2, while their rates of synthesis are marginally increased. Amino acid supplementation partially counteracts effects of thyroxine treatment. Amino acid supplementation of thyroxine-treated birds does not alter the plasma turnover rates of retinol-binding protein and prealbumin-2 but increases substentially their rates of synthesis. The release of vitamin A into circulation is interfered with in hyperthyroidism due to inadequate availability of retinol-binding protein being caused by enhanced plasma turnover rate not compensated for by synthesis.
Item Type: | Journal Article |
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Publication: | Biochimica et Biophysica Acta (BBA) |
Publisher: | Elsevier Science |
Additional Information: | Copyright of this article belongs to Elsevier Science. |
Department/Centre: | Division of Biological Sciences > Biochemistry |
Date Deposited: | 27 Sep 2010 11:53 |
Last Modified: | 27 Sep 2010 11:53 |
URI: | http://eprints.iisc.ac.in/id/eprint/32453 |
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